期刊
PPAR RESEARCH
卷 2012, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2012/891841
关键词
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资金
- Secretaria de Educacion Publica (SEP)-Consejo Nacional de Ciencia y Tecnologia-Mexico (CONACyT-Mexico) [55429]
- PAPIIT-Universidad Nacional Autonoma de Mexico
- Mexico City, Mexico [IT201912]
- CONACyT-Mexico
The main adipogenic transcription factor PPAR gamma possesses high affinity to 2,4-TZD, a member of the Thiazolidinedione family of insulin-sensitizing compounds used as adipogenic agents. We evaluated 2,4-TZD's effect on bovine growth and PPAR tissue expression. Seventeen Limousin bulls (18 month-old; 350 kg body weight (BW)) were assigned into 2 treatments: control and 2,4-TZD (8 mg/70 kg BW) and were fed until bulls reached 500 kg BW. They were weighed and their blood was sampled. DNA, RNA, and protein were determined in liver; skeletal muscle; subcutaneous (SC), omental, perirenal adipose tissues (AT) to determine protein synthesis rate and cellular size. Expression of PPAR mRNA was measured in liver and muscle (PPAR alpha, -delta, and -gamma) and SC adipose tissue (gamma) by real-time PCR. No significant differences were found (P > 0.1) in weight gain, days on feed, and carcass quality. Muscle synthesis was greater in controls (P < 0.05); cell size was larger with 2,4-TZD (P < 0.05). PPAR alpha, -delta, and -gamma expressions with 2,4-TZD in liver were lower (P < 0.01) than in muscle. No differences were found for PPAR gamma mRNA expression in SCAT. The results suggest the potential use of 2,4-TZD in beef cattle diets, because it improves AT differentiation, liver, and muscle fatty acid oxidation that, therefore, might improve energy efficiency.
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