期刊
PPAR RESEARCH
卷 2011, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2011/742785
关键词
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资金
- American Diabetes Association [1-10-JF-56]
- NIH [RO1-DK089098, NIH P30-DK34989]
- China Scholarship Council-Yale World Scholars in the Biomedical Sciences
Members of the nuclear receptor superfamily have vital roles in regulating immunity and inflammation. The founding member, glucocorticoid receptor (GR), is the prototype to demonstrate immunomodulation via transrepression of the AP-1 and NF-kappa B signaling pathways. Peroxisome proliferator-activated receptors (PPARs) have emerged as key regulators of inflammation. This review examines the history and current advances in nuclear receptor regulation of inflammation by the crosstalk with AP-1 and NF-kappa B signaling, focusing on the roles of GR and PPARs. A better understanding of the molecular mechanism by which nuclear receptors inhibit proinflammatory signaling pathways will enable novel therapies to treat chronic inflammation.
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