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Association of Pro12Ala polymorphism in the peroxisome proliferative-activated receptor γ2 gene with obesity and hypertension in Korean women
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ES Kang et al.
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Influence of the C161T but not Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma on colorectal cancer in an Indian population
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Influence of Pro12Ala peroxisome proliferator-activated receptor γ2 polymorphism on glucose response to exercise training in type 2 diabetes
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Inverse effects of the PPARγ2 Pro12Ala polymorphism on measures of adiposity over 15 years in African Americans and whites -: The CARDIA study
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Alcohol intake modulates the genetic association between HDL cholesterol and the PPARγ2 Pro12Ala polymorphism
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The peroxisome proliferator activated receptor gamma Pro12Ala polymorphism is associated with a lower hirsutism score and increased insulin sensitivity in women with polycystic ovary syndrome
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PPARγ in endothelial cells influences high fat diet-induced hypertension
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Implication of the Pro 12Ala polymorphism of the PPAR-gamma 2 gene in type 2 diabetes and obesity in the French population -: art. no. 11
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BMC MEDICAL GENETICS (2005)
The PPARγ Pro12Ala polymorphism and risk for incident sporadic colorectal adenomas
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Influence of the PPAR-γ2 Pro12Ala and ACE I/D polymorphisms on insulin sensitivity and training effects in healthy offspring of type 2 diabetic subjects
T Ostergård et al.
HORMONE AND METABOLIC RESEARCH (2005)
Peroxisorne proliferator-activated receptor-γ2 Pro12Ala and endothelial nitric oxide synthase-4a/b gene polymorphisms are not associated with hypertension in diabetes mellitus type 2
I Gouni-Berthold et al.
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A possible association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma 2 gene with obesity in native Javanese in Indonesia
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PPAR-gamma 2 Pro12Ala variant is associated with greater insulin sensitivity in childhood obesity
R Buzzetti et al.
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Differential effects of the C1431T and Pro12Ala PPARγ gene variants on plasma lipids and diabetes risk in an Asian population
ES Tai et al.
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RM Evans et al.
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Haplotype diversity across 100 candidate genes for inflammation, lipid metabolism, and blood pressure regulation in two populations
DC Crawford et al.
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Tyrosine Agonists reverse the molecular defects associated with dominant-negative mutations in human peroxisome proliferator-activated receptor γ
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Impact of genetic variation of PPARγ in humans
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MOLECULAR GENETICS AND METABOLISM (2004)
Genetic variation in PPARG encoding peroxisome proliferator-activated receptor γ associated with carotid atherosclerosis
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STROKE (2004)
Pro12A1a substitution in peroxisome proliferator-activated receptorγ2 is associated with low adiponectin concentrations in young Japanese men
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Effects of peroxisome proliferator-activated receptor-γ2 Pro12Ala polymorphism on body fat distribution in female Korean subjects
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Common polymorphisms of the PPAR-γ2 (Pro12Ala) and PGC-1α (Gly482Ser) genes are associated with the conversion from impaired glucose tolerance to type 2 diabetes in the STOP-NIDDM trial
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Gender specific association of genetic variation in peroxisome proliferator-activated receptor (PPAR)γ-2 with longevity
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The common PPAR-γ2 Pro12Ala variant is associated with greater insulin sensitivity
R Buzzetti et al.
EUROPEAN JOURNAL OF HUMAN GENETICS (2004)
Peroxisome proliferator-activated receptor γ induces a clearance mechanism for the amyloid-β peptide
IE Camacho et al.
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Does peroxisome proliferator-activated receptor gamma genotype (Pro12ala) modify the association of physical activity and dietary fat with fasting insulin level?
PW Franks et al.
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CS Carlson et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2004)
Gene-gene interaction between PPARγ2 and ADRβ3 increases obesity risk in children and adolescents
MC Ochoa et al.
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Lack of an association between peroxisome proliferator-activated receptor-γ gene Pro12Ala polymorphism and adiponectin levels in the polycystic ovary syndrome
F Orio et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2004)
Adipose-specific peroxisome proliferator-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle
WM He et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Combined effects of PPARγ2 P12A and PPARα L162V polymorphisms on glucose and insulin homeostasis:: The Quebec Family Study
Y Bossé et al.
JOURNAL OF HUMAN GENETICS (2003)
Muscle-specific Pparg deletion causes insulin resistance
AL Hevener et al.
NATURE MEDICINE (2003)
The human peroxisome proliferator-activated receptor γ2 (PPARγ2) Pro12Ala polymorphism is associated with decreased risk of diabetic nephropathy in patients with type 2 diabetes
ML Caramori et al.
DIABETES (2003)
Interaction between a peroxisome proliferator-activated receptor γ gene polymorphism and dietary fat intake in relation to body mass
A Memisoglu et al.
HUMAN MOLECULAR GENETICS (2003)
Evidence for genetic epistasis in human insulin resistance:: the combined effect of PC-1 (K121Q) and PPARγ2 (P12A) polymorphisms
R Baratta et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2003)
Prospective study of the association between the proline to aline codon 12 polymorphism in the PPARγ gene and type 2 diabetes
A Memisoglu et al.
DIABETES CARE (2003)
The association of Pro12Ala polymorphism in PPARγ2 with lower carotid artery IMT in Japanese
E Iwata et al.
DIABETES RESEARCH AND CLINICAL PRACTICE (2003)
The effects of the Pro12Ala polymorphism of the PPARγ-2 gene on lipid metabolism interact with body size at birth
J Eriksson et al.
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Liver peroxisome proliferator-activated receptor γ contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass
O Gavrilova et al.
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PPARγ and metabolism:: insights from the study of human genetic variants
M Gurnell
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Muscle-specific PPARγ-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones
AW Norris et al.
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Genetic epistasis of adiponectin and PPARγ2 genotypes in modulation of insulin sensitivity:: a family-based association study
WS Yang et al.
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Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor-γ
DB Savage et al.
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Liver-specific disruption of PPARγ in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes
K Matsusue et al.
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Polymorphism in the peroxisome proliferator-activated receptor-γ gene in women with polycystic ovary syndrome
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Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma (PPAR-γ) gene and risk of prostate cancer among men in a large cancer prevention study
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PPARγ gene polymorphism is associated with exercise-mediated changes of insulin resistance in healthy men
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The Pro12Ala polymorphism of PPAR gamma 2 gene and susceptibility to type 2 diabetes mellitus in a Polish population
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PPARG F388L, a transactivation-deficient mutant, in familial partial lipodystrophy
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Haplotype analysis of the PPARγ Pro12Ala and C1431T variants reveals opposing associations with body weight -: art. no. 21
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BMC GENETICS (2002)
PPARγ2 gene Pro12Ala polymorphism may influence serum level of an adipocyte-derived protein, adiponectin, in the Japanese population
Y Yamamoto et al.
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Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
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NATURE MEDICINE (2002)
Effect of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor γ-2 gene on adiposity, insulin sensitivity and lipid profile in the Spanish population
JLG Sánchez et al.
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Digenic inheritance of severe insulin resistance in a human pedigree
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Peroxisome proliferator-activated receptor-γ2 polymorphism Pro12Ala is associated with nephropathy in type 2 diabetes -: The Berlin Diabetes Mellitus (BeDiaM) Study
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M Hara et al.
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Pro12Ala substitution in the peroxisome proliferator-activated receptor-gamma is associated with increased leptin levels in women with type-2 diabetes mellitus
I Simon et al.
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A novel heterozygous mutation in peroxisome proliferator-activated receptor-gamma gene in a patient with familial partial lipodystrophy
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JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2002)
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J Schneider et al.
DIABETES (2002)
Interaction effect between common polymorphisms in PPAR gamma(2) (Pro12Ala) and insulin receptor substrate 1 (Gly972Arg) on insulin sensitivity
M Stumvoll et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2002)
Mutations of the peroxisome proliferator-activated receptor γ (PPARγ) gene in a Japanese population:: the Pro12Ala mutation in PPARγ2 is associated with lower concentrations of serum total and non-HDL cholesterol
E Iwata et al.
DIABETOLOGIA (2001)
Is the association between dietary fat intake and insulin resistance modified by physical activity?
AH Harding et al.
METABOLISM-CLINICAL AND EXPERIMENTAL (2001)
Genetic variation in the peroxisome proliferator-activated receptor-γ2 gene (Pro12Ala) affects metabolic responses to weight loss and subsequent weight regain
BJ Nicklas et al.
DIABETES (2001)
Opposite association of two PPARG variants with cancer:: overrepresentation of H449H in endometrial carcinoma cases and underrepresentation of P12A in renal cell carcinoma cases
WM Smith et al.
HUMAN GENETICS (2001)
Pro12Ala polymorphism in peroxisome proliferator-activated receptorγ2 (PPARγ2):: beta-cell function and insulin sensitivity
A Fritsche et al.
DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT (2001)
Effect of experimental elevation of free fatty acids on insulin secretion and insulin sensitivity in healthy carriers of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-γ2 gene
N Stefan et al.
DIABETES (2001)
Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-γ2 gene is associated with increased antilipolytic insulin sensitivity
M Stumvoll et al.
DIABETES (2001)
The Pro12→Ala substitution in PPAR-γ is associated with resistance to development of diabetes in the general population -: Possible involvement in impairment of insulin secretion in individuals with type 2 diabetes
H Mori et al.
DIABETES (2001)
Interactions between variants in the β3-adrenergic receptor and peroxisome proliferator-activated receptor-γ2 genes and obesity
WC Hsueh et al.
DIABETES CARE (2001)
A Pro12Ala polymorphism in the human peroxisome proliferator-activated receptor-γ2 is associated with combined hyperlipidaemia in obesity
MM Swarbrick et al.
EUROPEAN JOURNAL OF ENDOCRINOLOGY (2001)
Evidence for gene-nutrient interaction at the PPARγ locus
J Luan et al.
DIABETES (2001)
Association between the P12A and cl431t polymorphisms in the peroxisome proliferator activated receptor gamma (PPAR gamma) gene and type 2 diabetes
D Evans et al.
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES (2001)
A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis
A Chawla et al.
MOLECULAR CELL (2001)
The role of PPAR-gamma in macrophage differentiation and cholesterol uptake
KJ Moore et al.
NATURE MEDICINE (2001)
The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes
D Altshuler et al.
NATURE GENETICS (2000)
Treatment of insulin resistance with peroxisome proliferator-activated receptor γ agonists
JM Olefsky
JOURNAL OF CLINICAL INVESTIGATION (2000)
Significance of Pro12Ala mutation in peroxisome proliferator-activated receptor-γ2 in Korean diabetic and obese subjects
EY Oh et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2000)
Variation in the gene for human peroxisome proliferator activated receptor γ (PPARγ) does not play a major role in the development of morbid obesity
D Evans et al.
INTERNATIONAL JOURNAL OF OBESITY (2000)
The Pro12Ala polymorphism in PPAR γ2 may confer resistance to type 2 diabetes
K Hara et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)
The Pro12Ala variant of peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) is associated with measures of obesity in Mexican Americans
SA Cole et al.
INTERNATIONAL JOURNAL OF OBESITY (2000)
Inhibitory effect of a proline-to-alanine substitution at codon 12 of peroxisome proliferator-activated receptor-γ 2 on thiazolidinedione-induced adipogenesis
J Masugi et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)
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