相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Synthesis and identification of [1,2,4]thiadiazole derivatives as a new series of potent and orally active dual Agonists of peroxisome proliferator-activated receptors α and δ
Lan Shen et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
The next generation of PPAR drugs: Do we have the tools to find them?
Barry G. Shearer et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2007)
PPAR dual agonists: Are they opening Pandora's box?
Pitchal Balakumar et al.
PHARMACOLOGICAL RESEARCH (2007)
PPARα agonists suppress osteopontin expression in macrophages and decrease plasma levels in patients with type 2 diabetes
Takafumi Nakamachi et al.
DIABETES (2007)
MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity
Sandra E. Wiley et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Design and synthesis of a novel class of dual PPARγ/δ agonists
Isabel C. Gonzalez et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
Selective Modulators of PPAR-gamma Activity: Molecular Aspects Related to Obesity and Side-Effects
Fang Zhang et al.
PPAR RESEARCH (2007)
PPARα and PPARγ dual agonists for the treatment of type 2 diabetes and the metabolic syndrome
Catherine Fievet et al.
CURRENT OPINION IN PHARMACOLOGY (2006)
A simple method to screen ligands of peroxisome proliferator-activated receptor δ
Min-Chul Cho et al.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2006)
Design and synthesis of dual peroxisome proliferator-activated receptors γ and δ Agonists as novel euglycemic agents with a reduced weight gain profile
Yanping Xu et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Halofenate is a selective peroxisome proliferator-activated receptor γ modulator with antidiabetic activity
Tamara Allen et al.
DIABETES (2006)
Antagonism of peroxisome proliferator-activated receptor γ prevents high-fat diet-induced obesity in vivo
R Nakano et al.
BIOCHEMICAL PHARMACOLOGY (2006)
Fine tuning of PPAR ligands for type 2 diabetes and metabolic syndrome
U Ramachandran et al.
MINI-REVIEWS IN MEDICINAL CHEMISTRY (2006)
A novel partial agonist of peroxisome proliferator-activated receptor-γ (PPARγ) recruits PPARγ-coactivator-1α, prevents triglyceride accumulation, and potentiates insulin signaling in vitro
E Burgermeister et al.
MOLECULAR ENDOCRINOLOGY (2006)
PPARδ:: a dagger in the heart of the metabolic syndrome
GD Barish et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
Adipocyte-type fatty acid-binding protein as inter-compartmental shuttle for peroxisome proliferator activated receptor γ agonists in cultured cell
A Adida et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2006)
The role of peroxisome proliferator-activated receptor-beta/delta in epithelial cell growth and differentiation
AD Burdick et al.
CELLULAR SIGNALLING (2006)
The effect of dual PPAR alpha/gamma stimulation with combination of rosiglitazone and fenofibrate on metabolic parameters in type 2 diabetic patients
S Seber et al.
DIABETES RESEARCH AND CLINICAL PRACTICE (2006)
A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-γ
G Pascual et al.
NATURE (2005)
Effects of peroxisome proliferator-activated receptor α/δ agonists on HDL-cholesterol in vervet monkeys
JM Wallace et al.
JOURNAL OF LIPID RESEARCH (2005)
Ligand-binding regulation of LXR/RXR and LXR/PPAR heterodimerizations: SPR technology-based kinetic analysis correlated with molecular dynamics simulation
LD Yue et al.
PROTEIN SCIENCE (2005)
HX531, a retinoid X receptor antagonist, inhibited the 9-cis retinoic acid-induced binding with steroid receptor coactivator-1 as detected by surface plasmon resonance
T Kanayasu-Toyoda et al.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2005)
Dual and pan-peroxisome proliferator-activated receptors (PPAR) co-agonism: the bezafibrate lessons
Alexander Tenenbaum et al.
CARDIOVASCULAR DIABETOLOGY (2005)
An overview on biological mechanisms of PPARs
BP Kota et al.
PHARMACOLOGICAL RESEARCH (2005)
Leptin, from fat to inflammation:: old questions and new insights
M Otero et al.
FEBS LETTERS (2005)
Phosphorylation of PPARs: from molecular characterization to physiological relevance
C Diradourian et al.
BIOCHIMIE (2005)
Epitope analysis of PPAR gamma monoclonal antibody P gamma 48.34A and its application for screening PPAR gamma ligands
HS Lee et al.
JOURNAL OF IMMUNOLOGICAL METHODS (2005)
Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and Adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans
JN Fain et al.
ENDOCRINOLOGY (2004)
Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11β-hydroxysteroid dehydrogenase type 1-deficient mice
NM Morton et al.
DIABETES (2004)
A yeast two-hybrid technology-based system for the discovery of PPARγ agonist and antagonist
Q Chen et al.
ANALYTICAL BIOCHEMISTRY (2004)
Transcriptional activity of peroxisome proliferator-activated receptor γ is modulated by SUMO-1 modification
T Ohshima et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Binding analyses between human PPAR gamma-LBD and ligands - Surface plasmon resonance biosensor assay correlating with circular dichroic spectroscopy determination and molecular docking
CY Yu et al.
EUROPEAN JOURNAL OF BIOCHEMISTRY (2004)
Different ways to regulate the PPARα stability
C Blanquart et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
The transactivating function of peroxisome proliferator-activated receptor γ is negatively regulated by SUMO conjugation in the amino-terminal domain
D Yamashita et al.
GENES TO CELLS (2004)
Peroxisome proliferator-activated receptor γ in diabetes and metabolism
SM Rangwala et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2004)
Adiponectin, obesity, and cardiovascular disease
M Fasshauer et al.
BIOCHIMIE (2004)
Sequential gene promoter interactions by C/EBPβ, C/EBPα, and PPARγ during adipogenesis
QQ Tang et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
Activation of peroxisome proliferator-activated receptor δ induces fatty acid β-oxidation in skeletal muscle and attenuates metabolic syndrome
T Tanaka et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
In vitro farnesoid X receptor ligand sensor assay using surface plasmon resonance and based on ligand-induced coactivator association
T Fujino et al.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2003)
Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals
HJ Harwood et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Heat shock protein-90 (Hsp90) acts as a repressor of peroxisome proliferator-activated receptor-α (PPARα) and PPARβ activity
WK Sumanasekera et al.
BIOCHEMISTRY (2003)
Peroxisome proliferator-activated receptors, fatty acid oxidation, steatohepatitis and hepatocarcinogenesis
ST Yu et al.
CURRENT MOLECULAR MEDICINE (2003)
PPARγ and PPARδ negatively regulate specific subsets of lipopolysaccharide and IFN-γ target genes in macrophages
JS Welch et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
PPARγ is a very low-density lipoprotein sensor in macrophages
A Chawla et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Inhibition of cholesterol absorption associated with a PPAR alpha-dependent increase in ABC binding cassette transporter A1 in mice
BL Knight et al.
JOURNAL OF LIPID RESEARCH (2003)
Effects of the 11 beta-hydroxysteroid dehydrogrenase inhibitor carbenoxolone on insulin sensitivity in men with type 2 diabetes
RC Andrews et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2003)
Adipobiology of disease: Adipokines and adipokine-targeted pharmacology
GN Chaldakov et al.
CURRENT PHARMACEUTICAL DESIGN (2003)
A new selective peroxisome proliferator-activated receptor γ antagonist with antiobesity antidiabetic activity
J Rieusset et al.
MOLECULAR ENDOCRINOLOGY (2002)
Emerging roles of PPARs in inflammation and immunity
RA Daynes et al.
NATURE REVIEWS IMMUNOLOGY (2002)
Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss
P Cohen et al.
SCIENCE (2002)
WY14,643, a peroxisome proliferator-activated receptor α (PPARα) agonist, improves hepatic and muscle steatosis and reverses insulin resistance in lipoatrophic A-ZIP/F-1 mice
CJ Chou et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
New insights into the structure and function of fatty acid-binding proteins
AW Zimmerman et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2002)
Selective cooperation between fatty acid binding proteins and peroxisome proliferator-activated receptors in regulating transcription
NS Tan et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Optical biosensors in drug discovery
MA Cooper
NATURE REVIEWS DRUG DISCOVERY (2002)
Interferon-γ-mediated activation and ubiquitin-proteasome-dependent degradation of PPARγ in adipocytes
ZE Floyd et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Resistin and obesity-associated insulin resistance
CM Steppan et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2002)
ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism
AH Berg et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2002)
A transgenic model of visceral obesity and the metabolic syndrome
H Masuzaki et al.
SCIENCE (2001)
Role of AMP-activated protein kinase in mechanism of metformin action
GC Zhou et al.
JOURNAL OF CLINICAL INVESTIGATION (2001)
Use of homogeneous time-resolved fluorescence energy transfer in the measurement of nuclear receptor activation
GC Zhou et al.
METHODS (2001)
Fatty acid regulation of gene expression
PA Grimaldi
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2001)
Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of IKKβ
MS Yuan et al.
SCIENCE (2001)
A selective peroxisome proliferator-activated receptor δ agonist promotes reverse cholesterol transport
WR Oliver et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2
L Abu-Elheiga et al.
SCIENCE (2001)
New oral therapies for type 2 diabetes mellitus: The glitazones or insulin sensitizers
S Mudaliar et al.
ANNUAL REVIEW OF MEDICINE (2001)
Human genomics and obesity: finding appropriate drug targets
E Ravussin et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2000)
PPAR-γ agonists:: therapeutic role in diabetes, inflammation and cancer
GJ Murphy et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2000)
Activation of peroxisome proliferator-activated receptors (PPARs) by their ligands and protein kinase A activators
G Lazennec et al.
MOLECULAR ENDOCRINOLOGY (2000)
CLA-1/SR-BI is expressed in atherosclerotic lesion macrophages and regulated by activators of peroxisome proliferator-activated receptors
G Chinetti et al.
CIRCULATION (2000)
Thiazolidinediones: an update
K Schoonjans et al.
LANCET (2000)
Both coactivator LXXLL motif-dependent and -independent interactions are required for peroxisome proliferator-activated receptor γ (PPARγ) function
SY Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)