期刊
INTERNATIONAL JOURNAL OF ORAL SCIENCE
卷 2, 期 3, 页码 117-126出版社
SPRINGERNATURE
DOI: 10.4248/IJOS10042
关键词
salivary gland; epithelium; branching morphogenesis; fibronectin; E-cadherin; growth factor
资金
- National Institute of Dental and Craniofacial Research, NIH
- NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH [ZIADE000525] Funding Source: NIH RePORTER
Salivary glands provide saliva to maintain oral health, and a loss of salivary gland function substantially decreases quality-of-life. Understanding the biological mechanisms that generate salivary glands during embryonic development may identify novel ways to regenerate function or design artificial salivary glands. This review article summarizes current research on the process of branching morphogenesis of salivary glands, which creates gland structure during development. We highlight exciting new advances and opportunities in studies of cell-cell interactions, mechanical forces, growth factors, and gene expression patterns to improve our understanding of this important process.
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