期刊
EXPERT REVIEW OF HEMATOLOGY
卷 7, 期 6, 页码 807-818出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/17474086.2014.958464
关键词
acute myeloid leukemia; immunotherapy; microenvironment; tolerogenic; tumor immunity
类别
资金
- AIL Pesaro Onlus
Functional interplay between acute myeloid leukemia (AML) cells and the bone marrow microenvironment is a distinctive characteristic of this hematological cancer. Indeed, a large body of evidence suggests that proliferation, survival and drug resistance of AML are sustained and modulated by the bone marrow immunosuppressive microenvironment, where both innate and adaptive immune responses are profoundly deregulated. Furthermore, the presence of a number of different immunosuppressive mechanisms results in massive immune deregulation, which causes the eventual escape from natural immune control. Modulating the immune system, as documented by 40 years of stem cell transplantation, may improve survival of AML patients, as the immune system is clearly able to recognize and attack leukemic cells. The understanding of the factors responsible for the escape from immune destruction in AML, which becomes more prominent with disease progression, is necessary for the development of innovative immunotherapeutic treatment modalities in AML.
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