期刊
NETHERLANDS HEART JOURNAL
卷 18, 期 12, 页码 592-597出版社
BOHN STAFLEU VAN LOGHUM BV
DOI: 10.1007/s12471-010-0840-z
关键词
Tirofiban; Myocardial Infarction; Angioplasty; Timing of Drug Administration
Background. Despite the proven benefit of glycoprotein IIb/IIIa blockers in patients with acute ST-segment elevation myocardial infarction (STEMI), there is still debate on the timing of administration of these drugs and whether all or only a selection of patients should be treated. We evaluated the effect of routine upfront versus provisional use of high-dose tirofiban (HDT) in a large real-world population of non-selected STEMI patients. Methods. Consecutive STEMI patients were registered in a single-centre dedicated database. Patients with upfront HDT therapy before first balloon inflation were compared with patients who received the drug on a provisional basis, after first balloon inflation. Initial TIMI flow of the infarct-related vessel and enzymatic infarct size and 30-day clinical outcome were assessed. Results. Out of 2679 primary PCI patients HDT was given upfront in 885 (33.0%) and provisionally in 812 (45.3%). Upfront as compared with provisional HDT showed higher initial patency (22.3 vs. 17.9%, p= 0.006), smaller infarct size (1401 IU/l (IQR 609 to 2948) vs. 1620 (753 to 3132), p= 0.03) and a lower incidence of death or recurrent MI at 30 days (3.3 vs. 5.1%, p= 0.04) without an increase in TIMI bleeding (p= 0.24). Upfront HDT independently predicted initial patency (odds ratio (OR) 1.47, 95% confidence interval (CI) 1.15 to 1.88, p= 0.02), enzymatic infarct size (OR 0.70, 95% CI 0.56 to 0.86, p= 0.001) and 30-day death or recurrent MI (OR 0.59, 95% CI 0.37 to 0.95, p= 0.03). Conclusion. Our findings support the use of upfront potent antiplatelet and antithrombotic therapy in STEMI patients and encourage further clinical investigations in this field. (Neth Heart J 2010; 18: 592-7.)
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据