期刊
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
卷 6, 期 1, 页码 31-36出版社
SPRINGER
DOI: 10.1007/s12265-012-9416-1
关键词
LQT; Long-QT syndrome; Disease modeling; iPS cells; Reprogramming
资金
- European Research Council [ERC 261053-CHD-iPS]
- German Research Foundation [La 1238/3-1/4-1, Si 1747/1-1]
The generation of induced pluripotent stem cells (iPSC) from human somatic cells bears the possibility to generate patient-specific stem cell lines which can serve as a theoretically unlimited source of somatic cells carrying the genotype of the patients. Different types of the long-QT syndrome have been studied by analyzing the phenotype of cardiomyocytes generated from patient-specific iPSC lines. Major aspects of the pathophysiology of long-QT syndrome, like prolonged action potentials, arrhythmia, and the effects of pro- and antiarrhythmic drugs could be recapitulated in these cells. In the future, patient-specific iPSC-derived cardiomyocytes might be used to screen for new drugs, to avoid unwanted drug side effects, and to deepen our understanding on the pathophysiology of long-QT syndromes.
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