期刊
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
卷 3, 期 3, 页码 235-240出版社
SPRINGER
DOI: 10.1007/s12265-010-9164-z
关键词
MicroRNAs; Gene Regulation; Vascular Biology; Vascular Disease
资金
- National Institutes of Health [HL080133]
- American Heart Association [09GRNT2250567]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL080133] Funding Source: NIH RePORTER
MicroRNAs (miRNAs) have emerged as a novel class of endogenous, small, non-coding RNAs that negatively regulate over 30% of genes in a cell via degradation or translational inhibition of their target mRNAs. Functionally, an individual miRNA is important as a transcription factor because it is able to regulate the expression of its multiple target genes. Recent studies have identified that miRNAs are highly expressed in vasculature and their expression is deregulated in diseased vessels. miRNAs are found to be critical modulators for vascular cell functions such as cell differentiation, migration, proliferation, and apoptosis. Accordingly, miRNAs are involved in the angiogenesis and in the pathogenesis of vascular diseases. miRNAs may serve as novel biomarkers and therapeutic targets for vascular disease. This review article summarizes the research progress regarding the roles of miRNAs in vascular biology and vascular disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据