期刊
CELL DEATH & DISEASE
卷 5, 期 -, 页码 -出版社
SPRINGERNATURE
DOI: 10.1038/cddis.2014.146
关键词
AMP-activated protein kinase; autophagy; foam cell; transient receptor potential vanilloid subfamily 1; vascular smooth muscle cell
类别
资金
- National Natural Science Foundation of China [81271282]
- Natural Science Foundation Project of CQ CSTC [CSTC2012JJJQ10003]
Vascular smooth muscle cells (VSMCs) are an important origin of foam cells besides macrophages. The mechanisms underlying VSMC foam cell formation are relatively little known. Activation of transient receptor potential vanilloid subfamily 1 (TRPV1) and autophagy have a potential role in regulating foam cell formation. Our study demonstrated that autophagy protected against foam cell formation in oxidized low-density lipoprotein (oxLDL)-treated VSMCs; activation of TRPV1 by capsaicin rescued the autophagy impaired by oxLDL and activated autophagy-lysosome pathway in VSMCs; activation of TRPV1 by capsaicin impeded foam cell formation of VSMCs through autophagy induction; activation of TRPV1 by capsaicin induced autophagy through AMP-activated protein kinase (AMPK) signaling pathway. This study provides evidence that autophagy plays an important role in VSMC foam cell formation and highlights TRPV1 as a promising therapeutic target in atherosclerosis.
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