期刊
CELL DEATH & DISEASE
卷 4, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/cddis.2013.487
关键词
neurogenesis; cell fate specification; neural stem cells
类别
资金
- Marie Curie Fellowship
- German Research Foundation (DFG) [SCHW1392/2-1, SFB629, SPP1356, SCHW1392/4-1]
- Kompetenz-netzwerk Stammzellforschung NRW
- German-Israeli Foundation (GIF) for Scientific Research and Development [G-2226-2034.1/2009]
- Schram-Stiftung [T287/21795/2011]
- Else Kroner-Fresenius-Stiftung [2011_A94]
- fund 'Innovative Medical Research' of the University of Munster Medical School [SC120901, SC411003]
- Interdisciplinary Center for Clinical Research (IZKF) Munster [SchwJ3/001/11]
In the adult mammalian brain, neural stem cells in the subventricular zone continuously generate new neurons for the olfactory bulb. Cell fate commitment in these adult neural stem cells is regulated by cell fate-determining proteins. Here, we show that the cell fate-determinant TRIM32 is upregulated during differentiation of adult neural stem cells into olfactory bulb neurons. We further demonstrate that TRIM32 is necessary for the correct induction of neuronal differentiation in these cells. In the absence of TRIM32, neuroblasts differentiate slower and show gene expression profiles that are characteristic of immature cells. Interestingly, TRIM32 deficiency induces more neural progenitor cell proliferation and less cell death. Both effects accumulate in an overproduction of adult-generated olfactory bulb neurons of TRIM32 knockout mice. These results highlight the function of the cell fate-determinant TRIM32 for a balanced activity of the adult neurogenesis process.
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