期刊
AUTOPHAGY
卷 11, 期 10, 页码 1937-1938出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15548627.2015.1085136
关键词
BNIP3; cancer; hypoxia; HIF-1; mitophagy; mitochondrial dysfunction; ROS; Warburg effect
类别
资金
- NCATS NIH HHS [TL1 TR000432, UL1 TR000430] Funding Source: Medline
- NCI NIH HHS [T32 CA009594, R01 CA162405, R01 CA131188] Funding Source: Medline
There is a growing realization that tumor cells rely on healthy mitochondria to promote their growth under changing microenvironmental stresses and do so by dynamically modulating both their mitochondrial mass and state of mitochondrial fusion. Our recent work adds to this appreciation by showing that the mitophagy receptor BNIP3 functions as a tumor suppressor in mammary tumorigenesis and also as a prognostic indicator of progression to metastasis in certain sub-types of human breast cancer.
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