期刊
CELL DEATH & DISEASE
卷 2, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/cddis.2011.101
关键词
caspase-1; caspase-3; caspase-7; knockout; gut microbiome; pyrosequencing
类别
资金
- Fonds Wetenschappelijk Onderzoek 'FWO' Vlaanderen [G0226.09, 1.5.169.08, G.0875.11, G.0973.11]
- Ghent University
- Flanders Institute for Biotechnology
- Flemish Government [BOF09/01M00709]
- Institute for the encouragement of Scientific Research and Innovation of Brussels (ISRIB)
- FWO
- [MRTN-CT-035624]
- [FP7-200767]
- [IAP 6/18]
Caspases are aspartate-specific cysteine proteases that have an essential role in apoptosis and inflammation, and contribute to the maintenance of homeostasis in the intestine. These facts, together with the knowledge that caspases are implicated in host-microbe crosstalk, prompted us to investigate the effect of caspase (Casp) 1, -3 and -7 deficiency on the composition of the murine gut microbiota. We observed significant changes in the abundance of the Firmicutes and Bacteroidetes phyla, in particular the Lachnospiraceae, Porphyromonodaceae and Prevotellacea families, when comparing Casp-1, -7 and -3 knockout mice with wild-type mice. Our data point toward an intricate relationship between these caspases and the composition of the murine gut microflora. Cell Death and Disease (2011) 2, e220; doi: 10.1038/cddis.2011.101; published online 20 September 2011
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