期刊
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
卷 4, 期 12, 页码 -出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/cshperspect.a008250
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资金
- LOEWE Center for Cell and Gene Therapy Frankfurt [HMWK III L 4- 518/17.004]
- Georg-Speyer-Haus
- German Federal Ministry of Health (BMG)
- Ministry of Higher Education, Research and the Arts of the state of Hessen (HMWK)
Enormous numbers of adult blood cells are constantly regenerated throughout life from hematopoietic stem cells through a series of progenitor stages. Accessibility, robust functional assays, well-established prospective isolation, and successful clinical application made hematopoiesis the classical mammalian stem cell system. Most of the basic concepts of stem cell biology have been defined in this system. At the same time, many long-standing disputes in hematopoiesis research illustrate our still limited understanding. Here we discuss the embryonic development and lifelong maintenance of the hematopoietic system, its cellular components, and some of the hypotheses about the molecular mechanisms involved in controlling hematopoietic cell fates.
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