期刊
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
卷 3, 期 10, 页码 -出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/cshperspect.a005330
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资金
- Pardee Cancer Research Foundation
- National Institute of Health [GM087364, GM096070]
- American Cancer Society [RGS-09-278-01-CSM]
- University of Michigan Rackham Faculty
- NIH, Michigan Alzheimer's Disease Research Center [P50 AG08761]
The Golgi is an essential membrane-bound organelle in the secretary pathway of eukaryotic cells. In mammalian cells, the Golgi stacks are integrated into a continuous perinuclear ribbon, which poses a challenge for the daughter cells to inherit this membrane organelle during cell division. To facilitate proper partitioning, the mammalian Golgi ribbon is disassembled into vesicles in early mitosis. Following segregation into the daughter cells, a functional Golgi is reformed. Here we summarize our current understanding of the molecular mechanisms that control the mitotic Golgi disassembly and postmitotic reassembly cycle in mammalian cells.
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