期刊
CELL DIVISION
卷 6, 期 -, 页码 -出版社
BMC
DOI: 10.1186/1747-1028-6-2
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- NCI NIH HHS [R01 CA151521] Funding Source: Medline
- NIGMS NIH HHS [T32 GM008490] Funding Source: Medline
Because centrosome amplification generates aneuploidy and since centrosome amplification is ubiquitous in human tumors, a strong case is made for centrosome amplification being a major force in tumor biogenesis. Various evidence showing that oncogenes and altered tumor suppressors lead to centrosome amplification and aneuploidy suggests that oncogenes and altered tumor suppressors are a major source of genomic instability in tumors, and that they generate those abnormal processes to initiate and sustain tumorigenesis. We discuss how altered tumor suppressors and oncogenes utilize the cell cycle regulatory machinery to signal centrosome amplification and aneuploidy.
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