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Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy
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LKB1 is essential for the proliferation of T-cell progenitors and mature peripheral T cells
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LKB1 Deficiency in Tie2-Cre-expressing Cells Impairs Ischemia-induced Angiogenesis
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Spectrum of LKB1, EGFR, and KRAS Mutations in Chinese Lung Adenocarcinomas
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Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells
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The Lkb1 metabolic sensor maintains haematopoietic stem cell survival
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Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells
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ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS
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Somatic Alterations of the Serine/Threonine Kinase LKB1 Gene in Squamous Cell (SCC) and Large Cell (LCC) Lung Carcinoma
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LKB1 Regulates Pancreatic β Cell Size, Polarity, and Function
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Loss of Lkb1 in Adult β Cells Increases β Cell Mass and Enhances Glucose Tolerance in Mice
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Cardiac-specific Deletion of LKB1 Leads to Hypertrophy and Dysfunction
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Conditional deletion of the Lkb1 gene in the mouse mammary gland induces tumour formation
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JOURNAL OF PATHOLOGY (2009)
Identification of the Serine 307 of LKB1 as a Novel Phosphorylation Site Essential for Its Nucleocytoplasmic Transport and Endothelial Cell Angiogenesis
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Pten in stromal fibroblasts suppresses mammary epithelial tumours
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SADB phosphorylation of γ-tubulin regulates centrosome duplication
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NATURE CELL BIOLOGY (2009)
Inactivation of AMPK alters gene expression and promotes growth of prostate cancer cells
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ONCOGENE (2009)
Lkb1 Deficiency Alters Goblet and Paneth Cell Differentiation in the Small Intestine
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PLOS ONE (2009)
Somatic LKB1 Mutations Promote Cervical Cancer Progression
Shana N. Wingo et al.
PLOS ONE (2009)
mTOR and HIF-1α-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
The LKB1-AMPK pathway: metabolism and growth control in tumour suppression
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NATURE REVIEWS CANCER (2009)
Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice
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BIOCHEMICAL JOURNAL (2008)
Mutations in the LKB1 tumour suppressor are frequently detected in tumours from Caucasian but not Asian lung cancer patients
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Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas
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Lkb1 deficiency causes prostate neoplasia in the mouse
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CANCER RESEARCH (2008)
LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis
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CANCER RESEARCH (2008)
Loss of tuberous sclerosis complex-2 function and activation of mammalian target of rapamycin signaling in endometrial carcinoma
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LKB1 in endothelial cells is required for angiogenesis and TGFβ-mediated vascular smooth muscle cell recruitment
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DEVELOPMENT (2008)
Osteogenic tumours in Lkb1-deficient mice
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EXPERIMENTAL AND MOLECULAR PATHOLOGY (2008)
Lkb1 is required for TGFβ-mediated myofibroblast differentiation
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Pancreatic Lkb1 deletion leads to acinar polarity defects and cystic neoplasms
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MOLECULAR AND CELLULAR BIOLOGY (2008)
LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis
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NATURE GENETICS (2008)
LKB1; linking cell structure and tumor suppression
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ONCOGENE (2008)
Stromal inactivation of BMPRII leads to colorectal epithelial overgrowth and polyp formation
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ONCOGENE (2008)
Suppression of oncogenic properties of c-Myc by LKB1-controlled epithelial organization
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Prevalence and specificity of LKB1 genetic alterations in lung cancers
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LKB1 modulates lung cancer differentiation and metastasis
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LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons
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Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves, glucose homeostasis, and decreases TRB3
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Cancer risks in LKB1 germline mutation carriers
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Smad4 signalling in T cells is required for suppression of gastrointestinal cancer
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Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKα2 but not AMPKα1
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Accelerated onsets of gastric hamartomas and hepatic adenomas/carcinomas in Lkb1+/-p53-/- compound mutant mice
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Mutation of Lkb1 and p53 genes exert a cooperative effect on tumorigenesis
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The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
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Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction
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Mammalian SAD kinases are required for neuronal polarization
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Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD
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TGF-β signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia
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The LKB1 tumor suppressor negatively regulates mTOR signaling
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Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome
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High-resolution 19p13.2-13.3 allelotyping of breast carcinomas demonstrates frequent loss of heterozygosity
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GENES CHROMOSOMES & CANCER (2004)
Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer
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Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1
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Management of cellular energy by the AMP-activated protein kinase system
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FEBS LETTERS (2003)
Loss of Stk11/Lkb1 expression in pancreatic and biliary neoplasms
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A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity
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Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis
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Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation
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Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis
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STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreas
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