期刊
JOURNAL OF MOLECULAR CELL BIOLOGY
卷 4, 期 2, 页码 66-69出版社
OXFORD UNIV PRESS
DOI: 10.1093/jmcb/mjr045
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资金
- Ministry of Science and Technology [2009CB941102, 2011CB965200, 2011CBA01106]
- Chinese Academy of Sciences [XDA01020401, XDA01020106, XDA0102 0202, XDA01020404]
Cell fate determination is a major unsolved problem in cell and developmental biology. The discovery of reprogramming by pluripotent factors offers a rational system to investigate the molecular mechanisms associated with cell fate decisions. The idea that reprogramming of fibroblasts starts with a mesenchymal-epithelial transition (MET) suggests that the process is perhaps a reversal of epithelial to mesenchymal transition (EMT) found frequently during early embryogenesis. As such, we believe that investigations into MET-EMT may yield detailed molecular insights into cell fate decisions, not only for the switching between epithelial and mesenchymal cells, but also other cell types.
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