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注意：仅列出部分参考文献，下载原文获取全部文献信息。In Vitro Activity of the EWS Oncogene Transcriptional Activation Domain
King Pan Ng et al.
BIOCHEMISTRY (2009)
Combined use of expression and CGH arrays pinpoints novel candidate genes in Ewing sarcoma family of tumors
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Human U1 snRNA forms a new chromatin-associated snRNP with TAF15
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PRMT1 mediated methylation of TAF15 is required for its positive gene regulatory function
Laure Jobert et al.
EXPERIMENTAL CELL RESEARCH (2009)
O-GlcNAcylation is involved in the transcriptional activity of EWS-FLI1 in Ewing's sarcoma
R. Bachmaier et al.
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A Molecular Function Map of Ewing's Sarcoma
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PLOS ONE (2009)
Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6
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SCIENCE (2009)
Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis
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SCIENCE (2009)
Molecular Pathology of Sarcomas
Daniel Osuna et al.
REVIEWS ON RECENT CLINICAL TRIALS (2009)
Identification and characterization of FUS/TLS as a new target of ATM
Mary Gardiner et al.
BIOCHEMICAL JOURNAL (2008)
The multifunctional FUS, EWS and TAF15 proto-oncoproteins show cell type-specific expression patterns and involvement in cell spreading and stress response
Mattias K. Andersson et al.
BMC CELL BIOLOGY (2008)
The CTD role in cotranscriptional RNA processing and surveillance
Sergio F. de Almeida et al.
FEBS LETTERS (2008)
The DNA/RNA-binding protein, translin, binds microRNA122a and increases its in vivo stability
Zuoren Yu et al.
JOURNAL OF ANDROLOGY (2008)
EWS/FLI1 suppresses retinoblastoma protein function and senescence in Ewing's sarcoma cells
Hsien-Ming Hu et al.
JOURNAL OF ORTHOPAEDIC RESEARCH (2008)
Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription
Xiangting Wang et al.
NATURE (2008)
DAX1, a direct target of EWS/FLI1 oncoprotein, is a principal regulator of cell-cycle progression in Ewing's tumor cells
E. Garcia-Aragoncillo et al.
ONCOGENE (2008)
FUS-DDIT3 Prevents the Development of Adipocytic Precursors in Liposarcoma by Repressing PPARγ and C/EBPα and Activating eIF4E
Pedro A. Perez-Mancera et al.
PLOS ONE (2008)
Identification of proteins interacting with protein arginine methyltransferase 8: The Ewing sarcoma (EWS) protein binds independent of its methylation state
Steffen Pahlich et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2008)
Ewing Sarcoma Protein Ewsr1 Maintains Mitotic Integrity and Proneural Cell Survival in the Zebrafish Embryo
Mizuki Azuma et al.
PLOS ONE (2007)
Fat-specific FUS-DDIT3-transgenic mice establish PPARγ inactivation is required to liposarcoma development
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CARCINOGENESIS (2007)
EWS/FLI-1 oncoprotein subtypes impose different requirements for transformation and metastatic activity in a murine model
Iranzu Gonzalez et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2007)
Ewing sarcoma gene EWS is essential for meiosis and B lymphocyte development
Hongjie Li et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
Multiple aromatic side chains within a disordered structure are critical for transcription and transforming activity of EWS family oncoproteins
King Pan Ng et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Sarcomas: genetics, signalling, and cellular origins. Part I: The fellowship of TET
N. Riggi et al.
JOURNAL OF PATHOLOGY (2007)
An in vitro enzymatic assay coupled to proteomics analysis reveals a new DNA processing activity for Ewing sarcoma and TAF(II)68 proteins
Olivier Guipaud et al.
PROTEOMICS (2006)
Ewing's sarcoma family of tumors: Current management
Mark Bernstein et al.
ONCOLOGIST (2006)
Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma
Richard Smith et al.
CANCER CELL (2006)
The orphan nuclear receptor DAX1 is up-regulated by the EWS/FLI1 oncoprotein and is highly expressed in Ewing tumors
M Mendiola et al.
INTERNATIONAL JOURNAL OF CANCER (2006)
TLS facilitates transport of mRNA encoding an actin-stabilizing protein to dendritic spines
R Fujii et al.
JOURNAL OF CELL SCIENCE (2005)
Chromosome translocations in sarcomas and the emergence of oncogenic transcription factors
SJ Xia et al.
EUROPEAN JOURNAL OF CANCER (2005)
Towards a proteome-scale map of the human protein-protein interaction network
JF Rual et al.
NATURE (2005)
Different methylation characteristics of protein arginine methyltransferase 1 and 3 toward the Ewing sarcoma protein and a peptide
S Pahlich et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2005)
Rules of engagement: co-transcriptional recruitment of pre-mRNA processing factors
DL Bentley
CURRENT OPINION IN CELL BIOLOGY (2005)
Stimulation of Oct-4 activity by Ewing's sarcoma protein
JW Lee et al.
STEM CELLS (2005)
Context matters: The hen or egg problem in Ewing's sarcoma
H Kovar
SEMINARS IN CANCER BIOLOGY (2005)
The EWS-WT1 gene fusion in desmoplastic small round cell tumor
WL Gerald et al.
SEMINARS IN CANCER BIOLOGY (2005)
Delocalization of the multifunctional RNA splicing factor TLS/FUS in hippocampal neurones: exclusion from the nucleus and accumulation in dendritic granules and spine heads
A Belly et al.
NEUROSCIENCE LETTERS (2005)
Transcriptional down-regulation through nuclear exclusion of EWS methylated by PRMT1
N Araya et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
The RNA binding protein TLS is translocated to dendritic spines by mGluR5 activation and regulates spine morphology
R Fujii et al.
CURRENT BIOLOGY (2005)
RGG-boxes of the EWS oncoprotein repress a range of transcriptional activation domains
D Alex et al.
NUCLEIC ACIDS RESEARCH (2005)
Stimulation of hTAFII68 (NTD)-mediated transactivation by v-Src
HJ Lee et al.
FEBS LETTERS (2004)
P54nrb associates with the 5′ splice site within large transcription/splicing complexes
S Kameoka et al.
EMBO JOURNAL (2004)
Translocated in liposarcoma (TLS) is a substrate for fibroblast growth factor receptor-1
P Klint et al.
CELLULAR SIGNALLING (2004)
EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3
A Prieur et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Targeting of EWS/FLI-1 by RNA interference attenuates the tumor phenotype of Ewing's sarcoma cells in vitro
HA Chansky et al.
JOURNAL OF ORTHOPAEDIC RESEARCH (2004)
The Microprocessor complex mediates the genesis of microRNAs
RI Gregory et al.
NATURE (2004)
Domain Architectures and characterization of an RNA-binding protein, TLS
Y Iko et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Multiple links between transcription and splicing
AR Kornblihtt et al.
RNA (2004)
Expression and subcellular localization of Ewing sarcoma (EWS) protein is affected by the methylation process
LL Belyanskaya et al.
EXPERIMENTAL CELL RESEARCH (2003)
Proto-oncoprotein TLS/FUS is associated to the nuclear matrix and complexed with splicing factors PTB, SRm160, and SR proteins
M Meissner et al.
EXPERIMENTAL CELL RESEARCH (2003)
Cooperative interaction of EWS with CREB-binding protein selectively activates hepatocyte nuclear factor 4-mediated transcription
N Araya et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Alteration of mesodermal cell differentiation by EWS/FLI-1, the oncogene implicated in Ewing's sarcoma
S Eliazer et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
The Id2 gene is a novel target of transcriptional activation by EWS-ETS fusion proteins in Ewing family tumors
H Nishimori et al.
ONCOGENE (2002)
The SR protein SRp38 represses splicing in M phase cells
CS Shin et al.
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Multifunctional zinc finger proteins in development and disease
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Comprehensive proteomic analysis of the human spliceosome
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Large-scale proteomic analysis of the human splicesome
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GENOME RESEARCH (2002)
The pro-oncoprotein EWS (Ewing's sarcoma protein) interacts with the Brn-3a POU transcription factor and inhibits its ability to activate transcription
GR Thomas et al.
CANCER BIOLOGY & THERAPY (2002)
The Ewing's sarcoma oncoprotein EWS/FLI induces a p53-dependent growth arrest in primary human fibroblasts
SL Lessnick et al.
CANCER CELL (2002)
A unified nomenclature for TATA box binding protein (TBP)-associated factors (TAFs) involved in RNA polymerase II transcription
L Tora
GENES & DEVELOPMENT (2002)
Stimulatory effect of splicing factors on transcriptional elongation
YW Fong et al.
NATURE (2001)
DNA binding domain-independent pathways are involved in EWS/FLI1-mediated oncogenesis
SM Welford et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
EWS-ATF-1 chimeric protein in soft tissue clear cell sarcoma associates with CREB-binding protein and interferes with p53-mediated trans-activation function
Y Fujimura et al.
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Biology of EWS/ETS fusions in Ewing's family tumors
A Arvand et al.
ONCOGENE (2001)
Exposure on cell surface and extensive arginine methylation of ewing sarcoma (EWS) protein
LL Belyanskaya et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Role of protein methylation in chromatin remodeling and transcriptional regulation
MR Stallcup
ONCOGENE (2001)
An hsRPB4/7-dependent yeast assay for trans-activation by the EWS oncogene
HQ Zhou et al.
ONCOGENE (2001)
Identification of an RNA binding specificity for the potential splicing factor TLS
A Lerga et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Liposarcoma initiated by FUS/TLS-CHOP:: the FUS/TLS domain plays a critical Pole in the pathogenesis of liposarcoma
J Pérez-Losada et al.
ONCOGENE (2000)
EWS•Fli-1 fusion protein interacts with hyperphosphorylated RNA polymerase II and interferes with serine-arginine protein-mediated RNA splicing
L Yang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Translin binds to the sequences adjacent to the breakpoints of the TLS and CHOP genes in liposarcomas with translocation t(12;16)
T Hosaka et al.
ONCOGENE (2000)
BCR-ABL prevents c-Jun-mediated and proteasome-dependent FUS (TLS) proteolysis through a protein kinase CβII-dependent pathway
D Perrotti et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)
Transcriptional activation by the Ewing's sarcoma (EWS) oncogene can be cis-repressed by the EWS RNA-binding domain
KKC Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
The chimeric FUS/TLS-CHOP fusion protein specifically induces liposarcomas in transgenic mice
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ONCOGENE (2000)
TLS-ERG leukemia fusion protein inhibits RNA splicing mediated by serine-arginine proteins
L Yang et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)
Male sterility and enhanced radiation sensitivity in TLS-/- mice
M Kuroda et al.
EMBO JOURNAL (2000)
Fus deficiency in mice results in defective B-lymphocyte development and activation, high levels of chromosomal instability and perinatal death
GG Hicks et al.
NATURE GENETICS (2000)
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