期刊
GASTROENTEROLOGY RESEARCH AND PRACTICE
卷 2010, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2010/240365
关键词
-
资金
- Ministry of Education, Culture, Sports, Science and Technology, Takeda Science Foundation
- Mishima Kaiun Memorial Foundation
- Mochida Memorial Foundation for Medical and Pharmaceutical Research
- Naito Foundation
- Kowa Life Science Foundation
- Ohyama health Foundation
- Japan Spina Bifida & Hydrocephalus Research Foundation
- Yasuda Medical Foundation
- Kobayashi Foundation for Cancer Research
- KATO MEMORIAL TRUST FOR NAMBYO RESEARCH
- Osaka Cancer Foudation
- Showa Houkou Kai
- Japan Leuckemia Research Fund
- Kudo Gakujutsu Zaidan
On microbial invasion, the host immediately evokes innate immune responses. Recent studies have demonstrated that Toll-like receptors (TLRs) play crucial roles in innate responses that lead not only to the clearance of pathogens but also to the efficient establishment of acquired immunity by directly detecting molecules from microbes. In terms of intracellular TLR-mediated signaling pathways, cytoplasmic adaptor molecules containing Toll/IL-1R (TIR) domains play important roles in inflammatory immune responses through the production of proinflammatory cytokines, nitric oxide, and type I interferon, and upregulation of costimulatory molecules. In this paper, we will describe our current understanding of the relationship between TLRs and their ligands derived from pathogens such as viruses, bacteria, fungi, and parasites. Moreover, we will review the historical and current literature to describe the mechanisms behind TLR-mediated activation of innate immune responses.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据