期刊
SURGICAL INFECTIONS
卷 10, 期 5, 页码 457-461出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/sur.2008.062
关键词
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资金
- Allegheny-Singer Research Institute
- NIH NIDCR [DE014780]
- NIH [DC04173]
Background: Surgical site infection (SSI) is a common surgical complication; culture-negative SSI presents a particular problem in management. Methods: Examination of explanted foreign bodies (sutures) using confocal laser scanning microscopy (CLSM) and fluorescent in situ hybridization (FISH) after surgical exploration of a chronic culture-negative SSI. Results: Confocal microscopy (CM) demonstrated bacilli and cocci attached to the surface of the explanted sutures in a mixed biofilm. Florescent in situ hybridization confirmed that Staphylococci were components of the mixed biofilm. Removal of the foreign bodies (sutures) resolved the chronic infection. Conclusion: Chronic SSI can arise from underlying bacterial biofilms, which can invest implanted foreign bodies and associated soft tissue surfaces.
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