期刊
MATHEMATICAL MODELLING OF NATURAL PHENOMENA
卷 7, 期 1, 页码 166-202出版社
EDP SCIENCES S A
DOI: 10.1051/mmnp/20127199
关键词
multi-compartmental models; stem cell differentiation; environmental signaling; leukemia; cancer stem cells; leukemic stem cells; linear stability analysis
类别
资金
- ERC
- German Research Council (DFG)
The cancer stem cell hypothesis has evolved to one of the most important paradigms in biomedical research. During recent years evidence has been accumulating for the existence of stem cell-like populations in different cancers, especially in leukemias. In the current work we propose a mathematical model of cancer stem cell dynamics in leukemias. We apply the model to compare cellular properties of leukemic stem cells to those of their benign counterparts. Using linear stability analysis we derive conditions necessary and sufficient for expansion of malignant cell clones, based on fundamental cellular properties. This approach reveals different scenarios of cancer initiation and provides qualitative hints to possible treatment strategies.
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