期刊
ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 2
卷 2, 期 -, 页码 331-351出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-food-022510-133743
关键词
milk oligosaccharides; bifidobacteria; prebiotics
资金
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [R01HD059127, R01HD061923] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [R37ES002710, P01ES011269, R01ES002710] Funding Source: NIH RePORTER
- NICHD NIH HHS [R01 HD059127, 1R01HD061923, 5R01HD059127, R01 HD061923] Funding Source: Medline
- NIEHS NIH HHS [R37 ES002710, P01 ES11269, R01 ES002710, P01 ES011269, P42 ES02710] Funding Source: Medline
In addition to a nutritive role, human milk also guides the development of a protective intestinal microbiota in the infant. Human milk possesses an overabundance of complex oligosaccharides that are indigestible by the infant yet are consumed by microbial populations in the developing intestine. These oligosaccharides are believed to facilitate enrichment of a healthy infant gastrointestinal rnicrobiota, often associated with bifidobacteria. Advances in glycomics have enabled precise determination of milk glycan structures as well as identification of the specific glycans consumed by various gut microbes. Furthermore, genomic analysis of bifidobacteria from infants has revealed specific genetic loci related to milk oligosaccharide import and processing, suggesting coevolution between the human host, milk glycans, and the microbes they enrich. This review discusses the current understanding of how human milk oligosaccharides interact with the infant microbiota and examines the opportunities for translating this knowledge to improve the functionality of infant formulas.
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