期刊
JOURNAL OF FUNCTIONAL FOODS
卷 50, 期 -, 页码 8-17出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2018.09.027
关键词
EPA-PL; EPA-EE; Parkinson's disease; Apoptosis; Oxidative stress
资金
- National Key R&D Program of China [2018YFC0311201]
- National Natural Science Foundation of China Shandong Joint Fund for Marine Science Research Centers [U1606403]
- Fundamental Research Funds for the Central Universities [201762028]
Eicosapentaenoic acid (EPA) enriched phospholipids (EPA-PL) are widely distributed in marine products. It has been reported that the protective effects of the mixture of EPA and docosahexaenoic acid (DHA) on Parkinson's disease (PD), however, it is hard to confirm the improvement of EPA alone on PD. In the present study, EPA-PL was extracted from the sea cucumber (Cucumaria frondosa) to compare the effects of EPA-PL and commercial EPA in the form of ethyl ester (EPA-EE) on PD mice induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Results showed that dietary EPA-PL instead of EPA-EE notably improved MPTP-induced behavioral deficiency. Further research showed that EPA-PL suppressed MPTP-induced oxidative stress and apoptosis, thereby alleviating the loss of dopaminergic neurons via mitochondria - mediated pathway and mitogen-activated protein kinase pathway. These findings firstly confirmed that EPA-PL could improve MPTP-induced symptoms and pathology of PD, providing a reference for the prevention and treatment of neurodegenerative diseases.
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