期刊
JOURNAL OF FUNCTIONAL FOODS
卷 48, 期 -, 页码 515-524出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2018.07.048
关键词
Fucoxanthin; Type 2 diabetes mellitus; Insulin resistance; IRS-1/PI3K/Akt; AMPK
资金
- National Natural Science Foundation of China [81373940, 81673561, 81603525]
- Program for New Century Excellent Talents in Fujian Province University (2015)
- Natural Science Foundation of Fujian Province [2017J01838]
- Scientific Research Foundation of Third Institute of Oceanography of SOA [2017007, 2017026]
- Xiamen Southern Oceanographic Center [16PFW008SF15]
- Public Science and Technology Research Funds Projects of Ocean [201405017]
- Key Technology R&D Program of Fujian Province [2013N0101]
Fucoxanthin has potential anti-diabetic activities, but its precise effects and underlying mechanisms remain unclear. In this study, C57BL/KsJ-db/db mice were fed diets containing fucoxanthin (0.2% and 0.4%, w/w) for 6 weeks. Results showed dietary fucoxanthin significantly improved glucose/lipid metabolism and insulin resistance, and prevented pancreatic histological changes in db/db mice. Moreover, fucoxanthin markedly lowered blood glucose by regulating glucokinase and phosphoenolpyruvate carboxykinase mRNA expressions in liver, promoted glycogen synthesis by regulating glucose transporter 4, glycogen synthase and glycogen synthase kinase-3 beta protein expressions in skeletal muscle, and lowered blood lipid levels by regulating peroxisome proliferator-activated receptor alpha, p-acetyl CoA carboxylase, carnitine palmitoyltransferase 1 and fatty acid synthetase protein expressions in liver. Mechanistic studies indicated that fucoxanthin effectively regulates the expression of IRS-1/PI3K/AKT and AMPK signaling proteins in liver and skeletal muscle. All results suggested that fucoxanthin is a potential functional food or effective drug for type 2 diabetes mellitus.
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