期刊
JOURNAL OF FUNCTIONAL FOODS
卷 49, 期 -, 页码 196-204出版社
ELSEVIER
DOI: 10.1016/j.jff.2018.08.029
关键词
Black chokeberry fruits; Phenolics profile; Pancreatic lipase; Inhibitors; UPLC-MS
资金
- National Science Centre [DEC-2011/01/B/NZ9/02046]
- Wroclaw Centre of Biotechnology under program The Leading National Research Centre (KNOW - Poland) 2014-2018
In this study, the effects of a chokeberry fruit crude extract (CE), its ethyl acetate fractions (EAF7 & EAF2) and a polyphenol-rich fraction (PRF) on esterase and lipolytic activities of pancreatic lipase (PL) were investigated. Ethyl acetate fractions, rich in flavonols, phenolic acids and low molecular procyanidins, showed a week inhibitory activity against PL while the CE and PRF, which contained the highly polymerized procyanidins exhibited the highest anti-lipase activity. The kinetic study showed that the inhibitory mode of CE was noncompetitive while PRF behaved like the mixed type inhibitor. Cumulative effects were observed when orlistat was used with either CE or PRF. These results indicate that black chokeberry fruits are a source of PL inhibitors with proanthocyanidins as the most active compounds.
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