期刊
JOURNAL OF FUNCTIONAL FOODS
卷 9, 期 -, 页码 211-224出版社
ELSEVIER
DOI: 10.1016/j.jff.2014.04.021
关键词
Cynomoriurn songariurn; Mitochondrial uncoupling; Obesity; Glucose intolerance; Fatty liver
It has previously been demonstrated that HCY2, an ursolic acid-enriched fraction derived from Cynomorii Herba, induced mitochondrial uncoupling in heart, liver and kidney tissues of rats. In the present study, we investigated whether HCY2 co-treatment can reduce the body weight in high fat diet (HFD)-fed mice by virtue of mitochondrial uncoupling in skeletal muscle. The results showed that HCY2 co-treatment significantly reduced the body weight gain and white fat pads in HFD-fed mice. The weight reduction effect of HCY2 was associated with the induction of mitochondrial uncoupling in skeletal muscle, amelioration of HFD-induced hyperglycaemia and impairment in glucose tolerance as well as dyslipidaemia and fatty liver in HFD-fed mice. It is likely that HCY2 reduces body weight by increasing energy expenditure, presumably via mitochondrial uncoupling in skeletal muscle. HCY2 may therefore offer a promising prospect in preventing obesity and the associated metabolic syndrome and health consequences. (C) 2014 Elsevier Ltd. All rights reserved.
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