期刊
JOURNAL OF FUNCTIONAL FOODS
卷 6, 期 -, 页码 555-563出版社
ELSEVIER
DOI: 10.1016/j.jff.2013.11.022
关键词
Purification; Flavonoid; Cytotoxity; NMR; Litchi leaf
资金
- Guangdong Natural Science Funds for Distinguished Young Scholar [S2013050014131]
- Youth Innovation Promotion Association of Chinese Academy of Sciences
- Pearl River Science and Technology New Star Fund of Guangzhou
- International Foundation for Science [F/4451-2]
- Guangdong Natural Science Foundation [S2011020001156]
- Science and Technology Planning Project of Guangdong Province [2011A020102006]
- Special Fund for Agro-Scientific Research in the Public Interest [201303073]
- National Natural Science Foundation of China [3110122]
Six flavonoids, namely luteolin (1), epicatechin (2), kaempferol 3-O-beta-glucoside (3), kaempferol 3-O-alpha-rhamnoside (4), procyanidin A(2) (5) and rutin (6) were purified from the EtOAc-soluble extract of litchi leaf by column chromatography. Their structures were elucidated by nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS) evidences. Luteolin and kaempferol 3-O-alpha-rhamnoside were found from this plant for the first time. Procyanidin A(2) exhibited high anticancer activities against human hepatoma HepG2 and human cervical carcinoma Hela cells. However, it had poor anticancer activities against human lung cancer A549 and human breast cancer MCF-7 cells. Luteolin, epicatechin, procyanidin A(2) and rutin showed good antioxidant activities than butylated hydroxytoluene (BHT). The antimicrobial activity assay indicated that luteolin possessed the strongest antimicrobial activity against Staphylococcus aureus, Escherichia coli, Shigella dysenteriae, Salmonella and Bacillus thuringiensis. Epicatechin, procyanidin A(2) and rutin showed relatively weak antimicrobial activities. (C) 2013 Elsevier Ltd. All rights reserved.
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