期刊
JOURNAL OF FUNCTIONAL FOODS
卷 11, 期 -, 页码 509-516出版社
ELSEVIER
DOI: 10.1016/j.jff.2014.08.007
关键词
Tart cherry; Anthocyanins; Pharmacokinetics; Antioxidant
资金
- Cherry Research Committee of Cherry Marketing Institute, Lansing, MI, USA
- University of Michigan Clinical Research Unit of the Michigan Institute for Clinical and Health Research (from the United States National Institutes of Health) [M01-RR000042, UL1TR000433]
Anthocyanin-rich tart cherries may impart health benefits for oxidative stress and inflammation. Anthocyanin (ACN) pharmacokinetic studies often sample plasma and urine within hours of ingestion; these approaches do not reveal enterohepatic metabolites that may be critical for pharmacodynamic bioactivity. This study investigated ACN pharmacokinetics in healthy humans following intake of Montmorency tart cherries (Prunus cerasus). Using a within-subject crossover design, subjects (n = 12) ingested whole frozen tart cherries (45 or 90 cherries), and blood and urine samples were collected over 12 hours. LC-MS/MS identified two unmodified ACN in plasma and two ACN metabolites in urine. Intake of 45 cherries caused a biphasic antioxidant response, while 90 cherries caused a prolonged elevation over the 12 h period. The broad antioxidant peak beyond 8 h suggests that enterohepatic metabolites contribute to antioxidant pharmacodynamics. These findings should encourage extended pharmacokinetic studies with ACN-rich foods to reveal their breadth of bioavailability and bioactivity. (C) 2014 Elsevier Ltd. All rights reserved.
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