期刊
JOURNAL OF FUNCTIONAL FOODS
卷 8, 期 -, 页码 9-17出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2014.02.018
关键词
Mulberry; Diabetic rats; Carbohydrate metabolism; Antioxidant activity; Phenolics; High-fat diet
资金
- EU Project POIG [01.01.02.-00-061/09]
- Polish Ministry of Science and Higher Education [NN312209138]
This study evaluated the antioxidant activity and anti-diabetic effect of mulberry (Morus alba L. wielkolistna zolwinska) leaf extracts in diabetic rats fed a high-fat diet. After initial 4-week high-fat diet, streptozotocin was injected in Wistar rats to induce non-obese type 2 diabetes. After confirmation of diabetes, animals were treated with mulberry dried leaves, leaf-derived ethanol or acetone extracts added to high-fat diet for 4 weeks. Mulberry ethanol extract with higher level of phenolics - chlorogenic acid and flavonol glucosides was more effective than acetone extract or dry leaves in the lowering of blood glucose, increasing insulin level and markers of antioxidant activity. The results confirm key mechanisms related to the effect of mulberry and its bioactive components on modulation of glucose metabolism through correcting hyperglycaemia, increasing insulin secretion, and improving antioxidant status in STZ-induced non-obese diabetic rat model. Antidiabetic effects exerted by mulberry leaves might depend on the extraction process. (C) 2014 Elsevier Ltd. All rights reserved.
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