期刊
JOURNAL OF FUNCTIONAL FOODS
卷 6, 期 -, 页码 499-512出版社
ELSEVIER
DOI: 10.1016/j.jff.2013.11.016
关键词
Resistant starch; Cooking starch; Aberrant crypt foci; Mucin depleted foci; Gene expression; Short chain fatty acid
资金
- Plant Sciences Institute at Iowa State University (ISU)
- United States Department of Agriculture (USDA)
Stearic-acid-complexed-high-amylose-cornstarch (SAC) prevented preneoplastic lesions in the colon of azoxymethane (AOM)-treated Fisher344 rats fed cooked SAC for 8 weeks when water-boiling or bread-baking cooking methods were applied. Water-boiled-SAC (w-SAC) diet was compared with water-boiled-control-cornstarch (w-CS) or water-boiled-high-amylose-cornstarch (w-HA), and bread-baked-CS (b-CS) were compared with bread-baked-HA (b-HA) and bread-baked-SAC (b-SAC). Gene expression profiles from rats fed different water-boiled diets were determined. w-SAC or b-SAC markedly reduced pre-noeplasia compared with HA or CS. Increased cecal contents and decreased cecal pH were observed in SAC or HA groups. Total or individual (butyrate, acetate, and propionate) short-chain fatty acids (SCFAs) increased in selected SAC groups. Differentially expressed genes for AOM treatment were observed in rats fed w-CS and injected with AOM or saline (6428 genes), and for diet treatment in rats injected with AOM and fed w-CS or w-SAC (1403 genes). Changes in 7 genes (CACYBP, RhoA, MAPK1, TOPBP1, HSPH1, MCM6, and HSPD1) were confirmed with qRT-PCR. (C) 2013 Elsevier Ltd. All rights reserved.
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