期刊
JOURNAL OF FUNCTIONAL FOODS
卷 5, 期 4, 页码 1938-1946出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2013.09.015
关键词
Prebiotics; Gluco-oligosaccharides; Faecal fermentation; Gut microbiota
资金
- Sarawak Foundation
- Universiti Putra Malaysia of the Malaysian Government
- Tate Lyle
The aim of this study was to establish the effect of smaller molecular weight (0.5 and 1.0 kDa) on prebiotic efficacy and its putative sustainability in the human gut. The prebiotic effect of alpha-1,2 branched, 0.5 and 1 kDa dextrans were evaluated in faecal batch fermentations as compared with inulin. Both dextrans induce similar selectivity towards Bifidobacterium sp., Lactobacillus/Enterococcus and Bacteroides/Prevotella, and producing similar concentrations of short chain fatty acids. However, the 0.5 kDa dextran was fermented faster than the 1 kDa dextran, where both produced lower amount of gas than inulin. The fermentation of 1 kDa dextran was further investigated in continuous gut models. The dextran increased Bifidobacterium and Roseburia sp. populations in the final vessel, while decreasing Clostridium histolyticum and Faecalibacteriurn prausnitzii. Overall, the alpha-1,2 branched, 1 kDa dextran induced selective effect on the gut microbiota and stimulated short chain fatty acids, indicating prebiotic sustainability in distal regions of the gut. (C) 2013 Elsevier Ltd. All rights reserved.
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