Effects of broccoli sprout with high sulforaphane concentration on inflammatory markers in type 2 diabetic patients: A randomized double-blind placebo-controlled clinical trial

Anti-inflammatory therapeutic approaches are considered to be important in management of type 2 diabetes and prevention of its complication. This trial was conducted to evaluate the effects of broccoli sprouts powder (BSP) with high sulforaphane concentration, on inflammatory markers. Eighty-one patients with type 2 diabetes were randomly assigned to three treatment groups for 4 weeks. The groups received either 10 g/d BSP (n = 27), 5 Wd BSP (n = 29), or placebo (n = 25). Serum high-sensitive C reactive protein (hs-CRP), interleukin-6 (IL-6) and tumor necrosis alpha (TNF-alpha) were measured at baseline and 4 weeks after treatment. Sixty-three patients were included in the analysis: 10 g/d BSP (n = 21), 5 g/d (n = 22), placebo (n = 20). After 4 weeks, in the BSP treatment groups there was a significant decrease in serum hs-CRP concentration (-20.5% and -16.4%), and also non-significant decrease in serum IL-6 (-3.6% and -0.7%), and TNF-alpha concentration (-1.6% and -10.9%), in group A and B, respectively. Serum hs-CRP and IL-6 were lower in group A as compared to the controls after intervention. High-sulforaphane BSP had favorable effects on inflammatory markers in type 2 diabetic patients. (C) 2012 Elsevier Ltd. All rights reserved.