期刊
JOURNAL OF FUNCTIONAL FOODS
卷 4, 期 2, 页码 496-503出版社
ELSEVIER
DOI: 10.1016/j.jff.2012.02.010
关键词
Lingonberry; Cranberry; Blackcurrant; mRNA; Inflammation; SHR
资金
- Finnish Foundation of Nutrition Research
- Finnish Funding Agency for Technology and Innovation (TEKES)
Flavonoids and other phenolic compounds affect low-grade inflammation related to cardiovascular diseases among other positive health effects. Cardioprotective actions are mainly due to enhanced endothelial function and production of nitric oxide (NO). We investigated vascular anti-inflammatory effects of cranberry (Vaccinium oxycoccos), lingonberry (Vaccinium vitis-idaea) and blackcurrant (Ribes nigrum) juices given as drinking fluid ad libitum to spontaneously hypertensive rats (SHR), a widely used model of human hypertension, in an 8 week intervention study. The animals were sacrificed, the aortas cleaned and RNA was extracted. cDNA was prepared for real-time PCR and blood was collected for biochemical analyses. The mRNA expressions of angiotensin-converting enzyme 1 (ACE1), cyclooxygenase 2 (COX2), monocyte chemoattractant protein 1 (MCP1) and P-selectin were significantly reduced in the cranberry and lingonberry groups. These findings suggest that cranberry and lingonberry cold-compressed juices have anti-inflammatory and anti-atherothrombotic actions in long-term treatment of SHR. (C) 2012 Elsevier Ltd. All rights reserved.
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