期刊
JOURNAL OF FUNCTIONAL FOODS
卷 3, 期 3, 页码 135-143出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2011.03.006
关键词
Hoodia gordonii; Nutrikinetics; Food formulation; Bioavailability
Oral administration of extracts of the Hoodia gordonii (Hg.) plant reduced both food intake and body weight in healthy animals. Due to unfavorable physicochemical properties for gastrointestinal dissolution poor oral bioavailability was predicted for the steroid glycoside H.g.-12, a putative active compound in H. gordonii extract. Thus, absolute bioavailability of H.g.-12 was determined in pigs as a function of various dosage forms (colloidal nanoscale particles, nanoscale emulsion, mesophase, SEDDS or unformulated crude extract with or without a co-dosed meal). In a randomized cross over design plasma concentrations of H.g.-12 were determined by LC-MRM-MS analysis after intragastric or intravenous dose administration. Pharmacokinetic characteristics (absolute bioavailability, T(max), C(max) and mean absorption time) were determined by compartmental and non-compartmental analysis. Absolute bioavailability of H.g.-12 was 46 +/- 13.4% (mean +/- SD) and no meal or formulation dependent differences were seen. This result indicates that slow or incomplete gastrointestinal dissolution was not a limiting factor for systemic bioavailability, suggesting a large freedom of choice for the formulation of pi ducts containing H. gordonii extracts. (c) 2011 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据