期刊
JOURNAL OF FUNCTIONAL FOODS
卷 1, 期 4, 页码 366-374出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2009.09.003
关键词
Hypertension; Type 2 diabetes; Goto-Kakizaki rat; Bioactive peptides; Vascular function; Endothelium
资金
- Finnish Funding Agency for Technology and Innovation, TEKES
Increased blood pressure and plasma cholesterol concentration are the major risk factors for cardiovascular diseases. We have previously shown that fermented milk products containing casein-derived bioactive tripeptides, isoleucine-proline-proline (Ile-Pro-Pro) and valine-proline-proline (Val-Pro-Pro) partly inhibit the blood pressure increase in spontaneously hypertensive rats (SHR). In the present study, we investigated the effect of bioactive tripeptide-containing fermented milk products (with or without plant sterols) on blood pressure and vascular function in salt-loaded type 2 diabetic Goto-Kakizaki (GK) rats after 8 weeks' treatment. The development of blood pressure was attenuated in the groups receiving tripeptide-containing products (-10 to -12 mmHg vs. the control product group, P < 0.01). Tripeptide-containing products enhanced the impaired endothelium-dependent relaxation of mesenteric arteries. Also the role of endothelium-derived hyperpolarizing factor (EDHF) was demonstrated. Interestingly, pretreatment of arterial rings with verapamil normalized the impaired endothelial function. Endothelium-independent relaxations were similar between the groups. Furthermore, tripeptides had positive effects on renin-angiotensin-aldosterone system. (C) 2009 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据