期刊
MEDCHEMCOMM
卷 5, 期 4, 页码 432-435出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3md00335c
关键词
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资金
- Alzheimer's Drug Discovery Foundation
- Advion, Inc
The synthesis of fluorine-18 labeled 3-fluoro-5-[(pyridin-3-yl) ethynyl] benzonitrile ([F-18] FPEB) for imaging metabotropic glutamate receptor subtype type 5 (mGluR5) was achieved with a commercial continuousflow microfluidics device. This work represents the first positron emission tomography (PET) radiopharmaceutical that is suitable for human use with this technology. We also describe a validated synthesis of [18F] FPEB with a commercial reactor-based system.
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