期刊
MEDCHEMCOMM
卷 5, 期 7, 页码 879-885出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3md00324h
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资金
- Fund of the Science and Technology Commission of Shanghai Municipality [12520705500, 11nm0506400]
- National Natural Science Foundation of China [81101150, 21273032]
- High-Tech Research and Development Program of China [2012AA030309]
- Program for New Century Excellent Talents in University, State Education Ministry
- Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning
Generation 5 poly(amidoamine) dendrimers were used as a nanoplatform to conjugate covalently an anticancer drug, alpha-tocopheryl succinate (alpha-Tos) and targeting ligand folic acid (FA). The formed multifunctional dendrimers are able to endow the hydrophobic drug alpha-Tos with improved water solubility for targeted inhibition of cancer cells via an FA receptor-mediated targeting pathway.
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