期刊
MEDCHEMCOMM
卷 4, 期 6, 页码 956-961出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3md00077j
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资金
- Cancer Research at Bath (CR@B)
- University of Bath
- RCUK
The synthesis and antiproliferative activity of eleven 3-(pyrid-2-yl)-pyrazolines in two cancer cell lines are reported. X-ray crystallography was obtained of the lead compound 8i which was screened in the NCI 60 human tumour cell line and displayed sub-micromolar activity. Cell cycle analysis, in vitro tubulin assay and confocal microscopy are also reported and suggest that the lead compound disrupts microtubule formation.
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