期刊
MEDCHEMCOMM
卷 3, 期 11, 页码 1455-1461出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2md20134h
关键词
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资金
- Ministry of Education, Culture, Sports, Science and Technology, Japan
- Grants-in-Aid for Scientific Research [22112009, 24102526] Funding Source: KAKEN
New YC-1 derivatives were synthesized and evaluated with HIF-1 transcriptional activity, and a potent derivative shows activity in vivo. Furthermore, for the mechanistic study of the YC-1 derivative, we evaluate the antiproliferative activity against 39 human cancer cell lines and the localization of active probes in cells.
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