期刊
MEDCHEMCOMM
卷 2, 期 10, 页码 995-1000出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1md00146a
关键词
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资金
- French Ministry of Research (MESR)
- National Research Agency (ANR) [ANR-09-MIEN-001]
Bacterial infections are commonly treated with antibiotic chemotherapy. The biological targets of these antibiotics are at the origin of appearance of resistant bacterial strains. Recently, the development of new approaches, such as the antivirulence strategy leads the medicinal chemist to describe novel targets with a reduced probability of resistance development. Virulence factors, such as enzymes involved in amino acids biosynthesis, have been validated as such targets. In this paper, we describe the synthesis of a new class of histidinol dehydrogenase inhibitors: alpha-O-arylketones and alpha-S-aryl ketones derived from histidine.
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