Boronic acid-containing 4-anilinoquinazolines were synthesized as selective inhibitors of EGFR and VEGFR2 tyrosine kinases. The substituted position of the boronic acid is essential for control of both kinase inhibitions, and the boronic acid substituted at the para position of the aniline moiety exhibited significant inhibition of VEGFR2 tyrosine kinase.
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