期刊
COGNITIVE NEUROSCIENCE
卷 4, 期 3-4, 页码 143-151出版社
PSYCHOLOGY PRESS
DOI: 10.1080/17588928.2013.838945
关键词
Mild cognitive impairment; EEG; Memory; Alzheimer's disease; Event-related potentials
资金
- NIH [R01 AG18442, R01 AG08313, P30 AG10129, P50 AG05131]
- US Department of Veterans Affairs
- California Department of Public Health Alzheimer's Disease Program
We sought cognitive event-related potential (ERP) biomarkers of Preclinical Alzheimer's disease (Pre-AD) using an incidental verbal learning paradigm with high sensitivity to prodromal AD. Seven elderly persons, with normal cognition at the time of ERP recordings, but who showed subsequent cognitive decline or AD pathology at autopsy (n=5, mean Braak stage=2.8), were compared to 12 robust normal elderly (RNE) persons who remained cognitively normal (Mfollow-up=9.0 years). EEG was recorded during a word repetition paradigm (semantically congruous (50%) and incongruous target words repeat similar to 10-140 seconds later). The RNE P600 congruous word repetition ERP effects (New minus Old congruous words) were significantly larger than in Pre-AD (mean amplitudes=3.28vs. 0.10V, p=.04). High group discrimination (84%) was achieved (by a P600 amplitude cutoff of similar to 1.5V). Abnormal P600 word repetition effects in cognitively normal elderly persons may be an important sign of synaptic dysfunction and Preclinical AD.
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