期刊
FRONTIERS IN NEURAL CIRCUITS
卷 8, 期 -, 页码 -出版社
FRONTIERS RESEARCH FOUNDATION
DOI: 10.3389/fncir.2014.00037
关键词
Arc; neuronal ensemble; E-SARE; live imaging; activity-dependent gene expression; c-fos
资金
- Japanese Ministry of Education, Culture, Sports, Science, and Technology (MEXT)
- CREST-Japan Science and Technology Agency (JST)
- Strategic International Research Cooperative Program Japan-Mexico (SICPME-JST)
- Mitsubishi, Takeda and Uehara Foundation
- JSPS fellowships
- Japan Society for the Promotion of Science (JSPS)
- Grants-in-Aid for Scientific Research [25116507] Funding Source: KAKEN
Genetic labeling of neurons with a specific response feature is an emerging technology for precise dissection of brain circuits that are functionally heterogeneous at the single-cell level. While immediate early gene mapping has been widely used for decades to identify brain regions which are activated by external stimuli, recent characterization of the promoter and enhancer elements responsible for neuronal activity-dependent transcription have opened new avenues for live imaging of active neurons. Indeed, these advancements provided the basis for a growing repertoire of novel experiments to address the role of active neuronal networks in cognitive behaviors. In this review, we summarize the current literature on the usage and development of activity-dependent promoters and discuss the future directions of this expanding new field
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