期刊
FRONTIERS IN NEURAL CIRCUITS
卷 7, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fncir.2013.00160
关键词
optogenetics; channelrhodopsin; photostimulation; photoinhibition; cerebellum; cortex; hippocampus; pons
资金
- National Research Foundation of Singapore
- World Class Institute (WCI) Program of the National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology of Korea (MEST) (NRF) [WCI 2009-003]
- Grants-in-Aid for Scientific Research [21000009, 22115005, 25893287, 23300148] Funding Source: KAKEN
Here we characterize several new lines of transgenic mice useful for optogenetic analysis of brain circuit function. These mice express optogenetic probes, such as enhanced halorhodopsin or several different versions of channelrhodopsins, behind various neuron-specific promoters. These mice permit photoinhibition or photostimulation both in vitro and in vivo. Our results also reveal the important influence of fluorescent tags on optogenetic probe expression and function in transgenic mice.
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