期刊
FRONTIERS IN CELLULAR NEUROSCIENCE
卷 7, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fncel.2013.00178
关键词
microRNA; neurodegeneration; Alzheimer's disease; Parkinson's disease; amyotrophic lateral sclerosis; Huntington's disease
资金
- Motor Neurone Disease Association
- Medical Research Council
- Biotechnology and Biological Sciences Research Council
- Alzheimer's Research Trust
- Parkinson's UK
- EU Framework 7 grant (Euromotor) [259867]
- SOPHIA
- EU Joint Programme-Neurodegenerative Disease Research
- MRC [MR/K000039/1] Funding Source: UKRI
- Medical Research Council [MR/K000039/1] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0512-10082] Funding Source: researchfish
- Parkinson's UK [G-1202] Funding Source: researchfish
MicroRNAs (miRNAs) are small, abundant RNA molecules that constitute part of the cell's non-coding RNA dark matter. In recent years, the discovery of miRNAs has revolutionised the traditional view of gene expression and our understanding of miRNA biogenesis and function has expanded. Altered expression of miRNAs is increasingly recognized as a feature of many disease states, including neurodegeneration. Here, we review the emerging role for miRNA dysfunction in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS) and Huntington's disease pathogenesis. We emphasize the complex nature of gene regulatory networks and the need for systematic studies, with larger sample cohorts than have so far been reported, to reveal the most important miRNA regulators in disease. Finally, miRNA diversity and their potential to target multiple pathways, offers novel clinical applications for miRNAs as biomarkers and therapeutic agents in neurodegenerative diseases.
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