期刊
INTERNATIONAL WOUND JOURNAL
卷 13, 期 5, 页码 680-685出版社
WILEY-BLACKWELL
DOI: 10.1111/iwj.12346
关键词
IL-6; Inflammation; Macrophage; Muscle injury; TNF-alpha
资金
- National Science Council, R.O.C. [NSC 101-2628-H-028-002-MY3]
- China Medical University [CMU 99-COL-37]
Complex interactions exist between muscle repair processes and acute inflammatory responses that are initiated by exercise-induced muscle damage. The purpose of this study was to examine whether inflammatory mediators secreted by activated macrophages affect the migration of myogenic cells to the injury site. Migration was measured using a scratch wound closure assay in C2C12-derived myogenic cells incubated in activated macrophage-conditioned medium. Both myoblast and myotube migrations were significantly reduced in activated macrophage-conditioned medium compared with controlmedium. Furthermore, we demonstrated that the inhibitory effect on myoblast and myotube migrations was mediated, at least in part, by the two major cytokines secreted by activated macrophages, tumour necrosis factor (TNF)-alpha and interleukin (IL)-6. These findings suggest that the migration rate of myogenic cells may be reduced by inflammatory mediators. It may provide useful insights for future researches on the role of macrophages in the process of muscle repair and regeneration.
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