期刊
CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY
卷 20, 期 5, 页码 377-388出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.med.0000433067.01671.f5
关键词
cardiometabolic disease; complications; obesity; treatment algorithm; weight loss
资金
- Department of Veterans Affairs
- National Institutes of Health [DK-038765, DK-083562]
- UAB Diabetes Research Center [P60-DK079626]
- Merck
- Amylin
- Weight Watchers
Purpose of reviewThe current medical model for obesity management is BMI-centric because BMI is the predominant measure used to gauge disease severity, as well as indications for various treatment modalities. Recent advancements in therapy and understanding of the relationship between BMI and obesity-related complications call for a re-examination of this approach.Recent findingsAdvancements in treatment, including the recent approval of two new weight loss medications in the USA, have enabled development of new medical models for management of obesity. On the basis of accumulating data demonstrating the benefits of weight loss regarding multiple obesity-related complications (e.g., diabetes prevention, type 2 diabetes mellitus, cardiovascular disease risk, nonalcoholic steatohepatitis, sleep apnea), a complications-centric model is proposed that employs weight loss as a tool to treat and prevent obesity comorbidities. This model assures that the aggressiveness of therapy is commensurate with disease severity, and that therapy is directed at those obese patients who will benefit most from weight loss therapy. The treatment algorithm is comprehensive in addressing complications and quantitative when possible in the staging of risk or disease severity.SummaryA complications-centric approach to obesity management identifies patients who will benefit most from weight loss, and optimizes patient outcomes, benefit/risk ratio, and the cost-effectiveness of interventions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据