期刊
CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY
卷 18, 期 4, 页码 248-251出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MED.0b013e32834872ce
关键词
epidemiology; incidence; type 1 diabetes
资金
- National Institute of Diabetes and Digestive and Kidney Diseases [DK-32493, DK-32083, DK-50979]
- Diabetes Endocrinology Research Center (DERC) Clinical Investigation & Bioinformatics Core [P30 DK 57516]
- Children's Hospital Denver
Purpose of review Type 1 diabetes (T1D) is an autoimmune disorder which affects millions around the world. The incidence of T1D in children is increasing worldwide at a rate that cannot be explained by genetics alone. This review explores the recent research regarding possible causes of this epidemic. Recent findings Investigation into T1D epidemiology has recently focused on several hypotheses. These theories include the role of infections, early childhood diet, vitamin D exposure, environmental pollutants, increased height velocity, obesity, and insulin resistance in the risk for T1D. Over the past year, the evidence has strengthened for early childhood infections, dietary proteins, and insulin resistance as risk factors for T1D, but not for vitamin D exposure or environmental pollutants. Summary Investigation into the source of the current epidemic of T1D has shed light on several possible causes, but has not provided definitive answers, yet.
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