期刊
CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY
卷 17, 期 5, 页码 432-436出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MED.0b013e32833d9710
关键词
cancer; hypothyroxinemia; integrin alpha v beta 3; L-thyroxine; triiodothyronine
Purpose of review To collect and assess clinical reports of a putative relationship between thyroid state and the biology of cancers of various types. Recent findings A number of prospective case-control studies reviewed here have suggested that subclinical hyperthyroidism increases risk of certain solid tumors and that spontaneous hypothyroidism may delay onset or reduce aggressiveness of cancers. Small case studies have reached similar conclusions. A controlled prospective trial of induced hypothyroidism beneficially affected the course of glioblastoma. A context in which to interpret such findings is the recent description of a plasma membrane receptor for thyroid hormone on cancer cells and dividing tumor-associated endothelial cells. Summary Accumulating clinical evidence may justify new, broadly-based controlled studies in cancer patients of the possible contribution of thyroid hormone to tumor behavior.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据